Center for Clinical Genomics and Advanced Technology

2023

Periductal stromal tumor of the beast with a TERT promoter mutation: First case report with comprehensive molecular analysis. Anderson B, Marotti JD, Lefferts JA, Muller KE.Int J Surg Pathol. 2023 Feb 23:10668969231157306. doi: 10.1177/10668969231157306. Online ahead of print.PMID: 3682378

Validation of a rapid HLA-DQA1*05 pharmacogenomics assay to identify at risk resistance to anti-tumor necrosis factor therapy among patients with inflammatory bowel disease.  DelBaugh RM, Cook LJ, Siegel CA, Tsongalis GJ, Khan WA. Am J Clin Pathol. 2023 Aug 1;160(2):194-199. doi: 10.1093/ajcp/aqad036.PMID: 37086490

Multiple adult onset xanthogranulomas associated with skin dysbiosis: A presenting sign of common variable immune deficiency supported by next generation sequencing.  Salem I, Hodson EL, Davis MJ, Khan WA, Hughes EG, Cook LJ, Aaron DM, Sriharan A. JAAD Case Rep. 2023 Apr 5;36:4-7. doi: 10.1016/j.jdcr.2023.03.009. eCollection 2023 Jun.PMID: 37179956

Validation of a droplet digital PCR (ddPCR) assay to detect Cyanobacterial 16S rRNA in human lung tissue. Barney RE, Huang G, Gallagher TL, Tischbein M, DeWitt J, Martindale R, LaRochelle EMP, Tsongalis GJ, Stommel EW. Toxics. 2023 Jun 14;11(6):531. doi: 10.3390/toxics11060531.PMID: 37368631

Providing diagnostic pathology services in low and middle income countries. Ruhangaza D, Kennedy LS, Tsongalis GJ.Hematol Oncol Clin North Am. 2023 Jun 14:S0889-8588(23)00070-9. doi: 10.1016/j.hoc.2023.05.015. Online ahead of print.PMID: 37328312 Review.

A novel method to detect copy number variation in melanoma: Droplet digital PCR for quantitation of the CDKN2A gene, a proof of concept study. McFadden JR, Syku M, Barney RE, Stevanovic M, Chaudhari AS, O'Hern KJ, Chambers M, Baker CM, LeBlanc RE, Doan L, Tsongalis GJ, Hughes EG, Sriharan A. Am J Dermatopathol. 2023 Jul 1;45(7):454-462. doi: 10.1097/DAD.0000000000002436. Epub 2023 May 2.PMID: 37130203

Inferring spatial transcriptomics markers from whole sldie images to characterize metastasis-related spatial heterogeneity of colorectal tumors: A pilot study. Fatemi M, Feng E, Sharma C, Azher Z, Goel T, Ramwala O, Palisoul SM, Barney RE, Perreard L, Kolling FW, Salas LA, Christensen BC, Tsongalis GJ, Vaickus LJ, Levy JJ.J Pathol Inform. 2023 Mar 29;14:100308. doi: 10.1016/j.jpi.2023.100308. eCollection 2023.PMID: 371140.

Identification of spatial proteomic signatures of colon tumor metastasis: A digital spatial profiling appraoch. Levy JJ, Zavras JP, Veziroglu EM, Nasir-Moin M, Kolling FW, Christensen BC, Salas LA, Barney RE, Palisoul SM, Ren B, Liu X, Kerr DA, Pointer KB, Tsongalis GJ, Vaickus LJ.Am J Pathol. 2023 Jun;193(6):778-795. doi: 10.1016/j.ajpath.2023.02.020. Epub 2023 Apr 8.PMID: 37037284

Gain of CCND1 may occur too infrequently in cutaneous melanoma and too late in melanogenesis to be diagnsotically useful: Genome analysis of 88 cases. McFadden JR, Chaudhari AS, Stevanovic M, Tsongalis GJ, Hughes EG, Sriharan A. Am J Dermatopathol. 2023 May 1;45(5):311-319. doi: 10.1097/DAD.0000000000002420. Epub 2023 Mar 20.PMID: 36939129

Utility of retrospective molecular analysis in diagnostically challenging mesenchymal neoplasms.  Mindiola Romero AE, Tafe LJ, Green DC, Deharvengt SJ, Winnick KN, Tsongalis GJ, Baker ML, Linos K, Levy JJ, Kerr DA.Int J Surg Pathol. 2023 Mar 13:10668969231157783. doi: 10.1177/10668969231157783. Online ahead of print.PMID: 36911994

Molecular diagnostics and the laboratory developed test: A tale of success and the potential impacts of increased regulation. Tsongalis GJ.J Mass Spectrom Adv Clin Lab. 2023 Feb 1;28:27-29. doi: 10.1016/j.jmsacl.2023.01.007. eCollection 2023 Apr.PMID: 36825239

Potential impact of pharmacogenomic single nucleotide variants in a rural caucasian population.  Williams GR, Tsongalis GJ, Lewis LD, Barney RE, Cook LJ, Aaron Geno K, Nerenz RD. J Appl Lab Med. 2023 Mar 6;8(2):251-263. doi: 10.1093/jalm/jfac091.PMID: 36611001

Using molecular testing to improve the management of thyroid nodules with indeterminate cytology: an institutional expeerience with review of molecular alterations. Glass RE, Marotti JD, Kerr DA, Levy JJ, Vaickus LJ, Gutmann EJ, Tafe LJ, Motanagh SA, Sorensen MJ, Davies L, Liu X. J Am Soc Cytopathol. 2022 Mar-Apr;11(2):79-86.  PMID: 34627720 

Living the best of both worlds: A personal scientific journey. Tsongalis GJ. FASEB Bioadv. 2021 Nov 5;4(2):95-101. PMID: 35141473

Mammary-type Myofibroblastoma with Leiomyomatous Differentiation: A Rare Variant with Potential Pitfalls.    Strait AM, Bridge JA, Iafrate AJ, Li MM, Xu F, Tsongalis GJ, Linos K.   Int J Surg Pathol. 2022 Apr;30(2):200-206. PMID: 34338561

Mixed Effects Machine Learning Models for Colon Cancer Metastasis Prediction using Spatially Localized Immuno-Oncology Markers.   Levy JJ, Bobak CA, Nasir-Moin M, Veziroglu EM, Palisoul SM, Barney RE, Salas LA, Christensen BC, Tsongalis GJ, Vaickus LJ.   Pac Symp Biocomput. 2022;27:175-186.  PMID: 34890147

Plasmonic Nanoparticle Conjugation for Nucleic Acid Biosensing.    Tadimety A, Zhang Y, Molinski JH, Palinski TJ, Tsongalis GJ, Zhang JXJ.   Methods Mol Biol. 2022;2393:73-87.  PMID: 34837175 

CRISPR-cas13 enzymology rapidly detects SARS-CoV-2 fragments in a clinical setting.    Khan WA, Barney RE, Tsongalis GJ.   J Clin Virol. 2021 Dec;145:105019.  PMID: 34753073

High-Throughput CRISPR-Cas13 SARS-CoV-2 Test.    Manning BJ, Khan WA, Peña JM, Fiore ES, Boisvert H, Tudino MC, Barney RE, Wilson MK, Singh S, Mowatt JA, Thompson HJ, Tsongalis GJ, Blake WJ.   Clin Chem. 2021 Dec 30;68(1):172-180.   PMID: 34718481

Expanding Our Understanding of Nevogenesis: Copy Number Gain of Chromosome 15q in Melanocytic Nevi Is Associated With Distinct Histomorphologic Findings. Olson LC, Lefferts JA, LeBlanc RE, Yan S, Momtahen S, Sriharan A, Linos K. Am J Surg Pathol. 2021 Feb 9. doi: 10.1097/PAS.0000000000001683. Online ahead of print.Am J Surg Pathol. 2021. PMID: 33577183

Implementation of Reverse Transcriptase PCR Testing for Severe Acute Respiratory Syndrome Coronavirus 2 under the US Food and Drug Administration Emergency Use Authorization. Lefferts JA, Allen SF, Steinmetz HB, Tsongalis GJ. Clin Chem. 2021 Jan 30;67(2):434-435. PMID: 33315063

Cross reactivity of NRASQ61R antibody in a subset of Spitz nevi with 11p gain: A potential confounding factor in the era of pathway-based diagnostic approach. Parra O, Lefferts JA, Tafe LJ, Gru AA, Linos K. Hum Pathol. 2021 Feb 23:S0046-8177(21)00026-5. doi: 10.1016/j.humpath.2021.02.001. Online ahead of print.Hum Pathol. 2021. PMID: 33636207

Rare Activating BRAF Alteration Involving the β3-αC Kinase Domain in Ganglioglioma. Lin CC, Lefferts JA, Chan AM, Zanazzi G. J Neuropathol Exp Neurol. 2021 Feb 21:nlab013. doi: 10.1093/jnen/nlab013. Online ahead of print.J Neuropathol Exp Neurol. 2021. PMID: 33611593

Cytologic features of a case of mixed medullary and follicular cell-derived thyroid carcinoma with review of the literature. Chambers M, Tafe LJ, Gutmann EJ, Kerr DA. Diagn Cytopathol. 2021 Mar;49(3):E125-E129. PMID: 32936534

Proliferative potential and response to nivolumab in clear cell renal cell carcinoma patients. Zhang T, Pabla S, Lenzo FL, Conroy JM, Nesline MK, Glenn ST, Papanicolau-Sengos A, Burgher B, Giamo V, Andreas J, Wang Y, Bshara W, Madden KG, Shirai K, Dragnev K, Tafe LJ, Gupta R, Zhu J, Labriola M, McCall S, George DJ, Ghatalia P, Dayyani F, Edwards R, Park MS, Singh R, Jacob R, George S, Xu B, Zibelman M, Kurzrock R, Morrison C. Oncoimmunology. 2020 Jun 10;9(1):1773200. doi: 10.1080/2162402X.2020.1773200.Oncoimmunology. 2020. PMID: 32923131

Novel LRRFIP2-RAF1 fusion identified in an acral melanoma: A review of the literature on melanocytic proliferations with RAF1 fusions and the potential therapeutic implications. LeBlanc RE, Lefferts JA, Baker ML, Linos KD. J Cutan Pathol. 2020 Dec;47(12):1181-1186. PMID: 32700768

A Novel Case of Mammary-Type Myofibroblastoma With Sarcomatous Features.  Strait AM, Linos K, Tafe LJ, Muller KE. Int J Surg Pathol. 2020 Aug 5:1066896920947465. doi: 10.1177/1066896920947465. Online ahead of print.Int J Surg Pathol. 2020. PMID: 32752900

Concordance Analysis of the 23-Gene Expression Signature (myPath Melanoma) With Fluorescence In Situ Hybridization Assay and Single Nucleotide Polymorphism Array in the Analysis of Challenging Melanocytic Lesions: Results From an Academic Medical Center. Castillo SA, Pham AK, Dagrosa AT, Yan S, Barton DT, Lefferts JA, Linos K. Am J Dermatopathol. 2020 Dec;42(12):939-947. PMID: 32675469

Molecular matching and treatment strategies for advanced stage lung cancer at Dartmouth-Hitchcock Medical Center: A three-year review of a Molecular Tumor Board. Bernhardt EB, Chamberlin MD, Gorlov IP, de Abreu FB, Bloch KJ, Peterson JD, Tsongalis GJ, Shirai K, Dragnev KH, Miller TW, Tafe LJ. Pract Lab Med. 2020 Jun 12;21:e00174.  PMID: 32613070 

Lessons learned from Direct-to-Consumer genetic testing.  Petersen LM, Lefferts JA.Clin Lab Med. 2020 Mar;40(1):83-92. PMID: 32008642

Primary cutaneous Ewing sarcoma with diffuse S100/SOX10 positivity and pseudoalveolar pattern: An extraordinarily rare case highlighting a potential pitfall with significant repercussions.  Evangelou Z, Zhang L, Tafe LJ, Azzouz L, Grada Z, Linos K. J Cutan Pathol. 2021 Feb;48(2):302-308. PMID: 32592167 

A case of molecularly confirmed BAP1 Inactivated Melanocytic Tumor with retention of immunohistochemical expression: A confounding factor. Linos K, Atkinson A, Yan S, Tsongalis GJ, Lefferts JA.  J Cutan Pathol. 2020 (May); 47:485-489. PMID: 31891422 

Salivary-Like Tumors of the Thyroid: A Comprehensive Review of Three Rare Carcinomas.Chambers M, Nosé V, Sadow PM, Tafe LJ, Kerr DA. Head Neck Pathol. 2020 Jun 19. doi: 10.1007/s12105-020-01193-5. Online ahead of print.Head Neck Pathol. 2020. PMID: 32562215

Feasibility of brigade-style, multiphasic cancer screening in rural Honduras.  Lyons KD, Kennedy LS, LaRochelle EPM, Tsongalis GJ, Reyes HS, Zuniga-Moya JC, Chamberlin MD, Bruce ML, BejaranoS. Global Oncol 2020 March;6:453-461. PMID:32160013 

 A case report of papillary thyroid carcinoma dedifferentiated to squamous cell carcinoma presenting as a lung metastasis: A potential diagnostic pitfall Gadde R, Tafe LJ, Tsapakos MJ, Liu X. Diagn Cytopathol. 2020 Apr 9. doi: 10.1002/dc.24422. [Epub ahead of print] PMID: 32271487 

CD10 and p63 expression in a sarcomatid undifferentiated melanoma: A cautionary (and molecularlay annotated) tale.  Lefferts JA, Loehrer AP, Yan S, Green DC, Deharvengt SJ, LeBlanc RE.J Cutan Pathol. 2020 Jan 14.  PMID: 31943331

Rapid EGFR mutation testing in lung cancer tissue samples using a fully automated system and single-use cartridge. Al Turkmani MR, Suriawinata MA, Deharvengt SJ, Green DC, Black CC, Shirai K, Dragnev KH, Tsongalis GJ. J Pract Lab Med 2020 (Mar),PMID: 32181314.

Multi-Institutional Evaluation of Interrater Agreement of Variant Classification Based on the 2017 Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer. Sirohi D, Schmidt RL, Aisner DL, Behdad A, Betz BL, Brown N, Coleman JF, Corless CL, Deftereos G, Ewalt MD, Fernandes H, Hsiao SJ, Mansukhani MM, Murray SS, Niu N, Ritterhouse LL, Suarez CJ, Tafe LJ, Thorson JA, Segal JP, Furtado LV. J Mol Diagn. 2020 Feb;22(2):284-293.  PMID: 31837433

Non-Small Cell Lung Cancer as a Precision Oncology Paradigm: Emerging Targets and Tumor Mutational Burden (TMB).  Tafe LJ.  Adv Anat Pathol. 2020 Jan;27(1):3-10.  PMID: 31567128

Comparison of tissue molecular biomarker testing turnaround times and concordance between standard of care and the Biocartis Idylla™ platform in colorectal cancer patients. Tsongalis GJ, Al Turkmani MR, Suriawinata MA, Babcock MJ, Mitchell K, Ding Y, Scicchitano L, Tira A, Buckingham L, Atkinson S, Lax A, Aisner DL, Davies KD, Wood HN, O’Neill SS, Levine EA, Sequeira J, Harada S, DeFrank G, Paluri R, Tan BA, Colabella H, Snead C, Cruz-Correa M, Ramirez V, Rojas A, Huang H, Mackinnon AC, Garcia FU, Cavone SM, Elfaha M, Abel G, Vasef MA, Judd A, Linder MW, Alkhateeb K, Skinner WL, Boccia R, Patel K.Am J Clin Pathol. 2020, in press. 

Molecular genetic profiling reveals novel association between FLT3 mutation and survival in glioma. Shee K, Chambers M, Hughes EG, Almiron DA, Deharvengt SJ, Green D, Lefferts JA, Andrew AS, Hickey WF, Tsongalis GJ.  J Neurooncol. 2020 Jul;148(3):473-480. PMID: 32583303

MicroRNAs in graft-versus-host disease: a review of the latest data. Newmarch M, Kostantin E, Tsongalis GJ, Guimond M, Roy J, De Guire V, Ahmad I.Bone Marrow Transplant. 2019 Dec 3. PMID: 31796872

BRAF V600E mutations are not an oncogenic driver of solitary xanthogranuloma and reticulohistiocytoma: Testing may be useful in screening for Erdheim-Chester disease. Hoyt BS, Yan S, Linos KD, Momtahen S, Sriharan A, Tran TA, Tsongalis GJ, O’Meara RR, Green DC, LeBlanc RE. Exp Molec Pathol 2019 Dec. PMID:31639332

Third generation sequencing in the clinical laboratory: Exploring the advantages and challenges of nanopore sequencing. Petersen LM, Martin IW, Moschetti WE, Kershaw CM,Tsongalis GJ. J Clin Microbiol 2019 Oct.  PMID:31619531. 

Clinical validation of a 108-SNV MALDI-ToF MS pharmacogenomic panel.  Williams GR, Cook L, Lewis LD, Tsongalis GJ, Nerenz RD. J Appl Lab Med 2019; in press. 

Pure erythroid leukemia, presenting with pancytopenia. Images in Hematology.  Linnik Y, Batukbhai B, Loo E.Clin Case Rep. 2019 Aug 13;7(9):1829-1830. 

Significant expansion of real time PCR multiplexing with traditional chemistries using amplitude modulation. Rajagopal A, Yurk D, Shin C, Menge K, Jacky L, Frasser S, Tombrello TA, Tsongalis GJ. Nat Sci Rep 2019;9:1053. PMID:30705333

Design of peptide nucleic acid probes on plasmonic gold nanorods for detection of circulating tumor DNA point mutations. Tadimety A, Zhang Y, Kready KM, Palinski TJ, Tsongalis GJ, Zhang JXJ. Bioelectron. 2019 (Jan);130:236-244. PMID: 30769288

Pancreatic cyst fluid harboring a KRAS mutation. Al-Turkmani MR, Gordon SR, Smith KD, Tsongalis GJ, Liu X. Cold Spring Harb Mol Case Stud 2019 (Apr);5:1-6. PMID: 30936197

Screening for Human Papillomavirus in a Low- and Middle-Income Country. Atkinson AE, Mandujano CAM, Bejarano S, Kennedy LS, Tsongalis GJ. J Glob Oncol. 2019 (May);5:JGO1800233. doi: 10.1200/JGO.18.00233. PMID: 31050922

How close are miRNAs from clinical practice? A perspective on the diagnostic and therapeutic market.  Bonneau E, Neveu B, Kostantin E, Tsongalis GJ, De Guire V. EJIFCC. 2019 (Jun) 24;30(2):114-127. PMID:31263388 

Identifying Associations between Somatic Mutations and Clinicopathologic Findings in Lung Cancer Pathology Reports.Kumar N, Tafe LJ, Higgins JH, Peterson JD, de Abreu FB, Deharvengt SJ, Tsongalis GJ, Amos CI, Hassanpour S.Methods Inf Med. 2018 Feb;57(1):63-73. doi: 10.3414/ME17-01-0039. Epub 2018 Apr 5. PMID: 29621832

Rural distribution of human papilloma virus in low- and middle-income countries.Atkinson A, Studwell C, Bejarano S, Castellón AMZ, Espinal JAP, Deharvengt S, LaRochelle EPM, Kennedy LS, Tsongalis GJ.Exp Mol Pathol. 2018 Apr;104(2):146-150. doi: 10.1016/j.yexmp.2018.03.001. Epub 2018 Mar 16. PMID: 29551573

Potential of STAT Somatic Mutation Testing at Resection.Al-Turkmani MR, Schutz SN, Tsongalis GJ.Clin Chem. 2018 May;64(5):865-866. doi: 10.1373/clinchem.2017.285759. Epub 2018 Feb 26. No abstract available.
PMID: 29483108

Frequency of Somatic TP53 Mutations in Combination with Known Pathogenic Mutations in Colon Adenocarcinoma, Non-Small Cell Lung Carcinoma, and Gliomas as Identified by Next-Generation Sequencing.Shajani-Yi Z, de Abreu FB, Peterson JD, Tsongalis GJ.Neoplasia. 2018 Mar;20(3):256-262. doi: 10.1016/j.neo.2017.12.005. Epub 2018 Feb 16. PMID: 29454261

 Pharmacogenetics of opiod use and implications for pain management. Nerenz RD, Tsongalis GJ.   J Apll Lab Med 2018 (Jan);1:622-632.

Rapid somatic mutation testing in colorectal cancer by use of a fully automated system and single-use cartridge: A comparison with next generation sequencing. Al-Turkmani MR, Godwin KN, Peterson JD, Tsongalis GJ. J Appl Lab Med 2018 (Sept);3:178-184.

Maternally inherited 133 kb deletion of 14q32 causing Kagami-Ogata Syndrome. Jung HS, Vallee SE, Dinulos MB, Tsongalis GJ, Lefferts JA. J Hum Genet 2018 (Sept), PMID:30232357.

 Identifying aerosolized cyanobacteria in the human respiratory tract: A proposed mechanism for cyanotoxin-associated diseases.  Facciponte DN, Bough MW, Seidler D, Carroll JL, Ashare A, Andrew AS, Tsongalis GJ, Vaickus LJ, Henegan PL, Butt TH, Stommel EW. Sci Total Environ. 2018 (Dec), 15;645:1003-1013. PMID: 30248825 

Ductal Carcinoma in Situ Biomarkers in a Precision Medicine Era: Current and Future Molecular-Based Testing. Shee K, Muller KE, Marotti J, Miller TW, Wells WA, Tsongalis GJ. Am J Pathol. 2018 (Oct). PMID: 30385093

Somatic Mutation Analysis of Human Cancers: Challenges in Clinical Practice.Tsongalis GJ, Coleman WB.J Clin Pharmacol. 2017 Oct;57 Suppl 10:S60-S66. doi: 10.1002/jcph.934.
PMID: 28921651

Somatic mutation analysis in melanoma using targeted next generation sequencing.Miraflor AP, de Abreu FB, Peterson JD, Turner SA, Amos CI, Tsongalis GJ, Yan S.Exp Mol Pathol. 2017 Oct;103(2):172-177. PMID: 28822769

The Case for Laboratory Developed Procedures: Quality and Positive Impact on Patient Care.Kaul KL, Sabatini LM, Tsongalis GJ, Caliendo AM, Olsen RJ, Ashwood ER, Bale S, Benirschke R, Carlow D, Funke BH, Grody WW, Hayden RT, Hegde M, Lyon E, Murata K, Pessin M, Press RD, Thomson RB. Acad Pathol. 2017 Jul 16;4:2374289517708309. doi: 10.1177/2374289517708309. eCollection 2017 Jan-Dec.
PMID: 28815200 

Triple-Negative Breast Cancer: Next-Generation Sequencing for Target Identification.Marotti JD, de Abreu FB, Wells WA, Tsongalis GJ.Am J Pathol. 2017 Oct;187(10):2133-2138. PMID: 28734944

Development of HLA-B*57:01 Genotyping Real-Time PCR with Optimized Hydrolysis Probe Design.Jung HS, Tsongalis GJ, Lefferts JA.J Mol Diagn. 2017 Sep;19(5):742-754. PMID: 28732216

Not all good things come in big packages.Guire V, Fabbri M, Tsongalis GJ.Clin Chem Lab Med. 2017 May 1;55(5):605-607. PMID: 28343175

miRNA analysis in pancreatic cancer: the Dartmouth experience.Abreu FB, Liu X, Tsongalis GJ.Clin Chem Lab Med. 2017 May 1;55(5):755-762.
PMID: 28343174

Hyper-Methylated Loci Persisting from Sessile Serrated Polyps to Serrated Cancers.Andrew AS, Baron JA, Butterly LF, Suriawinata AA, Tsongalis GJ, Robinson CM, Amos CI.Int J Mol Sci. 2017 Mar 2;18(3). pii: E535. doi: 10.3390/ijms18030535.
PMID: 28257124

Variant call concordance between two laboratory-developed, solid tumor targeted genomic profiling assays using distinct workflows and sequencing instruments.Hampel KJ, de Abreu FB, Sidiropoulos N, Peterson JD, Tsongalis GJ.Exp Mol Pathol. 2017 Apr;102(2):215-218. PMID: 28192086

HS3ST1 genotype regulates antithrombin's inflammomodulatory tone and associates with atherosclerosis.Smits NC, Kobayashi T, Srivastava PK, Skopelja S, Ivy JA, Elwood DJ, Stan RV, Tsongalis GJ, Sellke FW, Gross PL, Cole MD, DeVries JT, Kaplan AV, Robb JF, Williams SM, Shworak NW.Matrix Biol. 2017 Nov;63:69-90. PMID: 28126521

Immune modulation associated with vascular endothelial growth factor (VEGF) blockade in patients with glioblastoma.Thomas AA, Fisher JL, Hampton TH, Christensen BC, Tsongalis GJ, Rahme GJ, Whipple CA, Steel SE, Davis MC, Gaur AB, Lewis LD, Ernstoff MS, Fadul CE.Cancer Immunol Immunother. 2017 Mar;66(3):379-389. PMID: 27942839

A Phase II Trial of Dovitinib in BCG-Unresponsive Urothelial Carcinoma with FGFR3 Mutations or Overexpression: Hoosier Cancer Research Network Trial HCRN 12-157.Hahn NM, Bivalacqua TJ, Ross AE, Netto GJ, Baras A, Park JC, Chapman C, Masterson TA, Koch MO, Bihrle R, Foster RS, Gardner TA, Cheng L, Jones DR, McElyea K, Sandusky GE, Breen T, Liu Z, Albany C, Moore ML, Loman RL, Reed A, Turner SA, De Abreu FB, Gallagher T, Tsongalis GJ, Plimack ER, Greenberg RE, Geynisman DM.Clin Cancer Res. 2017 Jun 15;23(12):3003-3011. PMID: 27932416

Role of microRNAs in regulation of the TNF/TNFR gene superfamily in chronic lymphocytic leukemia.Srivastava S, Tsongalis GJ, Kaur P.Clin Biochem. 2016 Nov;49(16-17):1307-1310.
PMID: 27544753

Improving Adequacy of Small Biopsy and Fine-Needle Aspiration Specimens for Molecular Testing by Next-Generation Sequencing in Patients With Lung Cancer: A Quality Improvement Study at Dartmouth-Hitchcock Medical Center.Padmanabhan V, Steinmetz HB, Rizzo EJ, Erskine AJ, Fairbank TL, de Abreu FB, Tsongalis GJ, Tafe LJ.Arch Pathol Lab Med. 2017 Mar;141(3):402-409.
PMID: 27763790

Detection of CALR Mutation in Clonal and Nonclonal Hematologic Diseases Using Fragment Analysis and Next-Generation Sequencing.Gardner JA, Peterson JD, Turner SA, Soares BL, Lancor CR, Dos Santos LL, Kaur P, Ornstein DL, Tsongalis GJ, de Abreu FB.Am J Clin Pathol. 2016 Oct;146(4):448-55. PMID: 27686171

The Use of Targeted Therapies for Precision Medicine in Oncology.White Al-Habeeb N, Kulasingam V, Diamandis EP, Yousef GM, Tsongalis GJ, Vermeulen L, Zhu Z, Kamel-Reid S.Clin Chem. 2016 Dec;62(12):1556-1564.
PMID: 27679436

Clinical Genotyping of Non-Small Cell Lung Cancers Using Targeted Next-Generation Sequencing: Utility of Identifying Rare and Co-mutations in Oncogenic Driver Genes.Tafe LJ, Pierce KJ, Peterson JD, de Abreu F, Memoli VA, Black CC, Pettus JR, Marotti JD, Gutmann EJ, Liu X, Shirai K, Dragnev KH, Amos CI, Tsongalis GJ.Neoplasia. 2016 Sep;18(9):577-83.
PMID: 27659017

The genomic profile of pancreatic adenocarcinoma and its relationship to metastatic disease.Pierce KJ, de Abreu FB, Peterson JD, Suriawinata AA, Tsongalis GJ, Liu X.Exp Mol Pathol. 2016 Oct;101(2):172-175.  
PMID: 27498048

Alpha-synuclein (SNCA) polymorphisms exert protective effects on memory after mild traumatic brain injury.Shee K, Lucas A, Flashman LA, Nho K, Tsongalis GJ, McDonald BC, Saykin AJ, McAllister TW, Rhodes CH.Neurosci Lett. 2016 Sep 6;630:241-246. PMID: 27478013 

Somatic gene mutation analysis of triple negative breast cancers.Dillon JL, Mockus SM, Ananda G, Spotlow V, Wells WA, Tsongalis GJ, Marotti JD.Breast. 2016 Oct;29:202-7.
PMID: 27397723

Targeted next-generation sequencing detects a high frequency of potentially actionable mutations in metastatic breast cancers.Muller KE, Marotti JD, de Abreu FB, Peterson JD, Miller TW, Chamberlin MD, Tsongalis GJ, Tafe LJ.Exp Mol Pathol. 2016 Jun;100(3):421-5. PMID: 27095739

The potential utility of re-mining results of somatic mutation testing: KRAS status in lung adenocarcinoma.Biernacka A, Tsongalis PD, Peterson JD, de Abreu FB, Black CC, Gutmann EJ, Liu X, Tafe LJ, Amos CI, Tsongalis GJ.Cancer Genet. 2016 May;209(5):195-8.
PMID: 27068338

Variation in pre-PCR processing of FFPE samples leads to discrepancies in BRAF and EGFR mutation detection: a diagnostic RING trial. Kapp JR, Diss T, Spicer J, Gandy M, Schrijver I, Jennings LJ, Li MM, Tsongalis GJ, Gonzalez de Castro D, Bridge JA, Wallace A, Deignan JL, Hing S, Butler R, Verghese E, Latham GJ, Hamoudi RA. J Clin Pathol 2015 Feb;68(2):111-8. PMID:25430497.  

A Multiplex PCR Assay for the Simultaneous Detection of Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis. Abou Tayoun AN, Burchard PR, Caliendo AM, Scherer A, Tsongalis GJ.  Exp Mol Pathol. 2015  Apr; 98(2):214-218. PMID:25595915

Regulatory T cells are not a strong predictor of survival for patients with glioblastoma. Thomas AA, Fisher JL, Rahme GJ, Hampton TH, Baron U, Olek S, Schwachula T, Rhodes CH, Gui J, Tafe LJ, Tsongalis GJ, Lefferts JA, Wishart H, Kleen J, Miller M, Whipple CA, de Abreu FB, Ernstoff MS, Fadul CE. Neuro Oncol. 2015 Jun; 17(6):801-809.  PMID: 25618892 

Rapid fluorescence in situ hybridisation (FISH) for HER2 (ERBB2) assessment in breast and gastro-oesophageal cancer. Tafe LJ, Steinmetz HB, Allen SF, Dokus BJ, Tsongalis GJ.  J Clin Pathol. 2015 Apr; 68(4):306-308. PMID: 25576545  

A 78-year old women with brain metastases. Tafe LJ, Tsongalis GJ. Clin Chem 2015 Apr 61(4):584-586.  

Implementation of a Molecular Tumor Board: The Impact on Treatment Decisions for 35 Patients Evaluated at Dartmouth-Hitchcock Medical Center.  Tafe LJ, Gorlov IP, de Abreu FB, Lefferts JA, Liu X, Pettus JR, Marotti JD, Bloch KJ, Memoli VA, Suriawinata AA, Dragnev KH, Fadul CE, Schwartz GN, Morgan CR, Holderness BM, Peterson JD, Tsongalis GJ, Miller TW, Chamberlin MD. Oncologist. 2015 Sep;20(9):1011-8. PMID:26205736  

Molecular profiling of intrahepatic and extrahepatic cholangiocarcinoma using next generation sequencing. Putra J, de Abreu FB, Peterson JD, Pipas JM, Mody K, Amos CI, Tsongalis GJ, Suriawinmata AA.  Exp Molec Pathol 2015; 99:240-244. PMID:26189129  

Rat-bite fever: An uncommon cause of fever and rash in a 9-year-old patient. Miraflor AP, Ghajar LD, Subramaniam S, de Abreu FB, Castanedo-Tardan MP, Samie FH, Mann JA, Holmes AV, Tsongalis GJ, Yan S.  J Am Acad Dermatol Case Reports 2015 (Oct), 1:371-374.  

Discovery of a novel cystathionine-beta-synthae mutation and diagnosis of homocystinuria by whole exome sequencing in a family from rural Honduras. Case report. Turner SA, Dinulos MBP, Vallee SE, Kennedy L, Mason P, Seibert D, Martinez MT, Steinmetz HB, Tsongalis GJ, Lefferts JA. Clin Pathol 2015 Sept;2(3):59-65.